FRAGMENTATION OF DNA IN P388D(1) MACROPHAGES EXPOSED TO OXIDIZED LOW-DENSITY-LIPOPROTEIN

被引：69

作者：

REID, VC

HARDWICK, SJ

MITCHINSON, MJ

机构：

[1] Division of Cellular Pathology, Department of Pathology, University of Cambridge, Cambridge, CB2 IQP, Tennis Court Road

来源：

FEBS LETTERS | 1993年 / 332卷 / 03期

关键词：

OXIDIZED LDL; MACROPHAGE; DNA FRAGMENTATION; APOPTOSIS; ATHEROSCLEROSIS;

D O I：

10.1016/0014-5793(93)80635-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.

引用

页码：218 / 220

页数：3

共 24 条

[1]

ANDREOLI SP, 1985, J LAB CLIN MED, V106, P253

[2] IDENTIFICATION OF MACROPHAGES AND SMOOTH-MUSCLE CELLS IN HUMAN ATHEROSCLEROSIS USING MONOCLONAL-ANTIBODIES [J].

AQEL, NM ;

BALL, RY ;

WALDMANN, H ;

MITCHINSON, MJ .

JOURNAL OF PATHOLOGY, 1985, 146 (03) :197-204

[3]

BROWN DG, 1993, J BIOL CHEM, V268, P3037

[4] LIPOPROTEIN METABOLISM IN THE MACROPHAGE - IMPLICATIONS FOR CHOLESTEROL DEPOSITION IN ATHEROSCLEROSIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :223-261

[5]

CARPENTER KLH, 1990, LIPOFUSCIN CEROID PI, P333

[6]

COHEN JJ, 1984, J IMMUNOL, V132, P38

[7] ENDOGENOUS ENDONUCLEASE-INDUCED DNA FRAGMENTATION - AN EARLY EVENT IN CELL-MEDIATED CYTOLYSIS [J].

DUKE, RC ;

CHERVENAK, R ;

COHEN, JJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6361-6365

[8] OXIDIZED LOW-DENSITY LIPOPROTEINS ELICIT DNA FRAGMENTATION OF CULTURED LYMPHOBLASTOID-CELLS [J].

ESCARGUEIL, I ;

NEGRESALVAYRE, A ;

PIERAGGI, MT ;

SALVAYRE, R .

FEBS LETTERS, 1992, 305 (02) :155-159

[9]

EVANS DL, 1993, CANCER RES, V53, P2133

[10] OVERLOADING HUMAN AORTIC SMOOTH-MUSCLE CELLS WITH LOW-DENSITY LIPOPROTEIN-CHOLESTERYL ESTERS REPRODUCES FEATURES OF ATHEROSCLEROSIS INVITRO [J].

GOLDSTEIN, JL ;

ANDERSON, RGW ;

BUJA, LM ;

BASU, SK ;

BROWN, MS .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (06) :1196-1202

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