INFLUENCE OF XENOBIOTICS ON BILE-FLOW AND BILE COMPOSITION IN RATS - METHODOLOGICAL APPROACH

被引：17

作者：

FLECK, C

BARTH, A

机构：

[1] Friedrich Schiller University Jena, Institute of Pharmacology and Toxicology, Jena

来源：

EXPERIMENTAL PATHOLOGY | 1990年 / 39卷 / 3-4期

关键词：

age; bile acids; bile flow; electrolytes; glutathione; hepatic excretion; lipids; liver; nephrectomy; rats; steroid hormones;

D O I：

10.1016/S0232-1513(11)80181-7

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Optimal procedures for the investigation of bile flow and excretion of bile constituents are described, and data are given regarding sex and age dependency, use of narcotic drugs and replacement of water loss in Wistar rats. A combination of ketamine and xylazine can be recommended for anaesthesia. In long time studies saline infusion keeps bile and urine production constant over a period of 6h. Bile flow and biliary excretion of bile acids and electrolytes are immature at birth and reach a maximum between the 20th and 60th day of life. The biliary excretion of cholesterol decreases with age. The concentrations of bile constituents such as lipids, glutathione, protein, uric acid, urea, osmotically active substances, and steroid hormones are given for adult rats. Bilateral nephrectomy decreases bile flow in mature rats only. © 1990, VEB Gustav Fischer Verlag Jena. All rights reserved.

引用

页码：175 / 185

页数：11

共 41 条

[1]

ADAMS JD, 1983, J PHARMACOL EXP THER, V227, P749

[2]

BARTH A, 1981, ACTA BIOL MED GER, V40, P1723

[3]

BARTH A, 1977, Z VERSUCHSTIERKD, V19, P26

[4]

BLITZER BL, 1982, GASTROENTEROLOGY, V82, P346

[5]

BRAUNLICH H, 1968, ACTA BIOL MED GER, V21, P459

[6]

Carey M. C., 1982, LIVER BIOL PATHOBIOL, P429

[7]

ECKENHOFF JE, 1960, CLIN PHARMACOL THER, V1, P483

[8]

ERLINGER S, 1982, LIVER BIOL PATHOBIOL, P407

[9] AGE DEPENDENCE OF HEPATIC TRANSPORT IN CONTROL AND PHENOBARBITAL-PRETREATED RATS [J].

FISCHER, E ;

BARTH, A ;

VARGA, F ;

KLINGER, W .

LIFE SCIENCES, 1979, 24 (06) :557-561

[10] RELATION BETWEEN RENAL AND HEPATIC EXCRETION OF DRUGS .10. EXCRETION OF NALORPHINE IN YOUNG AND ADULT-RATS PRETREATED WITH HORMONES OR XENOBIOTICS [J].

FLECK, C ;

SCHULTZ, M ;

SEIDEL, D ;

BRAUNLICH, H .

EXPERIMENTAL PATHOLOGY, 1988, 34 (03) :171-180

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