MATERNAL SMOKING IN PREGNANCY - DOES IT INCREASE THE RISK OF CHILDHOOD-CANCER

被引:73
作者
PERSHAGEN, G
ERICSON, A
OTTERBLADOLAUSSON, P
机构
[1] NATL BOARD HLTH & WELF, DEPT PUBL HLTH & EPIDEMIOL, STOCKHOLM, SWEDEN
[2] KAROLINSKA HOSP, DEPT ENVIRONM HLTH, S-10401 STOCKHOLM 60, SWEDEN
关键词
D O I
10.1093/ije/21.1.1
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Experimental studies show that some compounds in tobacco smoke are transplacental carcinogens, but epidemiological data on maternal smoking and childhood cancer are inconclusive. Using the national Swedish Medical Birth and Cancer Registries, the incidence of cancer was followed through 1987 in a cohort of 497051 children born 1982-1987 for whom information was available on maternal smoking at 2-3 months of pregnancy. A total of 327 cancers appeared including 198 solid tumours and 129 cancers of the lymphatic and haematopoietic system. The overall relative risk for cancer in children with mothers reporting smoking during pregnancy was 0.99 (95% confidence interval (Cl): 0.78-1.27). Corresponding risks for solid tumours and cancers of the lymphatic/haematopoietic system were 0.96 (0.70-1.32) and 1.04 (0.71-1.52), respectively. There was no consistent increase in risk for cancer of different sites or in relation to number of cigarettes smoked per day.
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页码:1 / 5
页数:5
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