THE INHIBITORY EFFECT OF NORHARMAN ON MORPHINE-WITHDRAWAL SYNDROME IN RATS - COMPARISON WITH IBOGAINE

被引：47

作者：

CAPPENDIJK, SLT ^{[1
]}

FEKKES, D ^{[1
]}

DZOLJIC, MR ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT PSYCHIAT,3000 DR ROTTERDAM,NETHERLANDS

来源：

BEHAVIOURAL BRAIN RESEARCH | 1994年 / 65卷 / 01期

关键词：

IBOGAINE; MORPHINE DEPENDENCE; MORPHINE WITHDRAWAL; NALOXONE; NORHARMAN; RAT;

D O I：

10.1016/0166-4328(94)90080-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Norharman (20 mg/kg, i.p.) and ibogaine (40 mg/kg, i.p.) significantly attenuated naloxone (4 mg/kg, i.p.)-precipitated withdrawal syndrome in morphine-dependent rats. Several withdrawal signs, such as teeth-chattering, chewing, penile licking and diarrhoea, were decreased by both norharman and ibogaine. In addition, norharman reduced also the withdrawal grooming and rearing. It is concluded that both norharman and ibogaine are inhibitors of withdrawal syndrome in morphine-dependent rats.

引用

页码：117 / 119

页数：3

共 20 条

[1]

AANONSEN LM, 1987, J PHARMACOL EXP THER, V243, P9

[2]

AIRAKSINEN MM, 1981, MED BIOL, V59, P190

[3] REGULATION OF GASTROINTESTINAL FUNCTION BY MULTIPLE OPIOID RECEPTORS [J].

BURKS, TF ;

FOX, DA ;

HIRNING, LD ;

SHOOK, JE ;

PORRECA, F .

LIFE SCIENCES, 1988, 43 (26) :2177-2181

[4]

Cappendijk S L, 1993, Eur Neuropsychopharmacol, V3, P111, DOI 10.1016/0924-977X(93)90262-K

[5] INHIBITORY EFFECTS OF IBOGAINE ON COCAINE SELF-ADMINISTRATION IN RATS [J].

CAPPENDIJK, SLT ;

DZOLJIC, MR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 241 (2-3) :261-265

[6] MECHANISMS OF ACTION OF IBOGAINE AND HARMALINE CONGENERS BASED ON RADIOLIGAND BINDING-STUDIES [J].

DEECHER, DC ;

TEITLER, M ;

SODERLUND, DM ;

BORNMANN, WG ;

KUEHNE, ME ;

GLICK, SD .

BRAIN RESEARCH, 1992, 571 (02) :242-247

[7] ACTION OF SOME HARMALA ALKALOIDS ON TRANSMISSION AT A GLUTAMATE-MEDIATED SYNAPSE [J].

DOWSON, RJ ;

CLEMENTS, AN ;

MAY, TE .

NEUROPHARMACOLOGY, 1975, 14 (03) :235-240

[8]

DZOLJIC ED, 1988, ARCH INT PHARMACOD T, V294, P64

[9] HALLUCINOGENIC PLANTS - VARIOUS CHEMICAL SUBSTANCES ARE KNOWN TO BE ACTIVE HALLUCINOGENIC PRINCIPLES IN MANY PLANTS [J].

FARNSWOR.NR .

SCIENCE, 1968, 162 (3858) :1086-+

[10]

GLANTZ SA, 1989, PRIMER BIOSTATISTICS

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