EFFECTS OF APOMORPHINE AND L-METHIONINE SULFOXIMINE ON THE RELEASE OF EXCITATORY AMINO-ACID NEUROTRANSMITTERS AND GLUTAMINE IN THE STRIATUM OF THE CONSCIOUS RAT

被引:27
作者
EXPOSITO, I [1 ]
SANZ, B [1 ]
PORRAS, A [1 ]
MORA, F [1 ]
机构
[1] UNIV COMPLUTENSE MADRID,FAC MED,DEPT PHYSIOL,E-28040 MADRID,SPAIN
关键词
DOPAMINE; GLUTAMIC ACID; ASPARTIC ACID; GLUTAMINE;
D O I
10.1111/j.1460-9568.1994.tb00271.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effects of apomorphine, a D1-, D2-dopamine receptor agonist, on the extracellular concentrations of excitatory amino acids, glutamic and aspartic acids, and on that of their precursor, glutamine, were investigated using an intracerebral perfusion system. Apomorphine produced a concentration-related rise in glutamic acid concentration in cerebral perfusates (P < 0.01) whereas only the highest Concentration of apomorphine (3 x 10(-3) mu g/mu l) increased the concentration of aspartic acid (P < 0.05). These effects were seen in the sample taken at the same time as the apomorphine injection. The rise in glutamine concentration (P < 0.01) produced by apomorphine continued for 10 min beyond perfusion with apomorphine. These effects were attenuated by previous injections of a D1-, D2-dopamine receptor blocker. To investigate further the release of glutamine, the glutamine synthetase inhibitor L-methionine sulphoximine (MSG) was injected intracerebrally before apomorphine perfusion. After MSO pre-injection, the extracellular concentration of glutamine decreased (P < 0.01) to near zero concentrations. In MSG-treated animals, apomorphine did not induce the release of glutamic acid, aspartic acid or glutamine. These results indicate a role for dopamine in the release of excitatory amino acids and glutamine in the neostriatum of the rat. A possible volumetric interaction between dopamine and glutamic acid as well as the hypothesis of a striato-pallido-thalamo-cortico-striatal feedback loop are discussed.
引用
收藏
页码:287 / 291
页数:5
相关论文
共 41 条
[1]   ACTIVATION OF THE BILATERAL CORTICOSTRIATAL GLUTAMATERGIC PROJECTION BY INFUSION OF GABA INTO THALAMIC MOTOR NUCLEI IN THE CAT - AN INVIVO RELEASE STUDY [J].
BARBEITO, L ;
GIRAULT, JA ;
GODEHEU, G ;
PITTALUGA, A ;
GLOWINSKI, J ;
CHERAMY, A .
NEUROSCIENCE, 1989, 28 (02) :365-374
[2]   CHEMICAL AND STRUCTURAL-ANALYSIS OF THE RELATION BETWEEN CORTICAL INPUTS AND TYROSINE HYDROXYLASE-CONTAINING TERMINALS IN RAT NEOSTRIATUM [J].
BOUYER, JJ ;
PARK, DH ;
JOH, TH ;
PICKEL, VM .
BRAIN RESEARCH, 1984, 302 (02) :267-275
[3]   AMPHETAMINE-INDUCED DOPAMINE RELEASE IN THE RAT STRIATUM - AN INVIVO MICRODIALYSIS STUDY [J].
BUTCHER, SP ;
FAIRBROTHER, IS ;
KELLY, JS ;
ARBUTHNOTT, GW .
JOURNAL OF NEUROCHEMISTRY, 1988, 50 (02) :346-355
[4]   INTERACTIONS BETWEEN GLUTAMATERGIC AND MONOAMINERGIC SYSTEMS WITHIN THE BASAL GANGLIA - IMPLICATIONS FOR SCHIZOPHRENIA AND PARKINSONS-DISEASE [J].
CARLSSON, M ;
CARLSSON, A .
TRENDS IN NEUROSCIENCES, 1990, 13 (07) :272-276
[5]   INTERACTIONS BETWEEN DOPAMINE AND AMINO ACID-INDUCED EXCITATION AND INHIBITION IN THE STRIATUM [J].
CHIODO, LA ;
BERGER, TW .
BRAIN RESEARCH, 1986, 375 (01) :198-203
[6]   ACIDIC AMINO-ACIDS AND SELF-STIMULATION OF THE PREFRONTAL CORTEX IN THE RAT - A PHARMACOLOGICAL STUDY [J].
COBO, M ;
MORA, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (06) :531-538
[7]   RELEASE OF AMINO-ACID NEUROTRANSMITTERS IN DIFFERENT CORTICAL AREAS OF CONSCIOUS ADULT AND AGED RATS [J].
COBO, M ;
EXPOSITO, I ;
PORRAS, A ;
MORA, F .
NEUROBIOLOGY OF AGING, 1992, 13 (06) :705-709
[8]  
FONNUM F, 1991, FID RES FDN, V5, P15
[9]   TERMINAL EXCITABILITY OF THE CORTICOSTRIATAL PATHWAY .2. REGULATION BY GLUTAMATE RECEPTOR STIMULATION [J].
GARCIAMUNOZ, M ;
YOUNG, SJ ;
GROVES, PM .
BRAIN RESEARCH, 1991, 551 (1-2) :207-215
[10]   TERMINAL EXCITABILITY OF THE CORTICOSTRIATAL PATHWAY .1. REGULATION BY DOPAMINE RECEPTOR STIMULATION [J].
GARCIAMUNOZ, M ;
YOUNG, SJ ;
GROVES, PM .
BRAIN RESEARCH, 1991, 551 (1-2) :195-206