SELECTIVE BRAIN COOLING INCREASES CORTICAL CEREBRAL BLOOD-FLOW IN RATS

被引：65

作者：

KULUZ, JW ^{[1
]}

PRADO, R ^{[1
]}

CHANG, J ^{[1
]}

GINSBERG, MD ^{[1
]}

SCHLEIEN, CL ^{[1
]}

BUSTO, R ^{[1
]}

机构：

[1] UNIV MIAMI, SCH MED, CEREBRAL VASC DIS RES CTR, DEPT NEUROL, MIAMI, FL 33101 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 03期

关键词：

HYPOTHERMIA; CEREBRAL VASCULAR RESISTANCE; TEMPERATURE; LASER-DOPPLER FLOWMETRY;

D O I：

10.1152/ajpheart.1993.265.3.H824

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38-degrees-C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 +/- 26% (mean +/- SE) of baseline at a cortical brain temperature of 30.9 +/- 0.5-degrees-C and a rectal temperature of 37.5 +/- 0.1-degrees-C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.

引用

页码：H824 / H827

页数：4

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