ACETYLATION OF A HETEROCYCLIC ENAMINONITRILE - UNAMBIGUOUS STRUCTURAL ASSIGNMENT USING NMR METHODS

被引：11

作者：

DELL, CP

HOWE, TJ

PROWSE, WG

机构：

[1] Lilly Research Centre Limited, Eli Lilly and Company, Windlesham, Surrey

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 04期

关键词：

D O I：

10.1002/jhet.5570310410

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using a combination of nmr techniques, the structure of the acetylation product of methyl 3-[2-amino-3-cyano-9-methoxy-4H-5,6-dihydronaphtho[1,2-b]pyran-4-yl] benzoate 2b has been shown to be the N-acetyl derivative 5a, rather than the rearranged 2-acetoxydihydropyridine 6a.

引用

页码：749 / 755

页数：7

共 18 条

[1] A FACILE SYNTHESIS OF 6-ALKOXY-2,4-DIARYL-5-CYANOPYRIDINE
ALARAB, MM
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1989, 26 (06) : 1665 - 1673
[2] DETERMINATION OF HETERONUCLEAR COUPLING-CONSTANTS VIA SEMISELECTIVE TWO-DIMENSIONAL J-SPECTROSCOPY
BAX, A
[J]. JOURNAL OF MAGNETIC RESONANCE, 1983, 52 (02) : 330 - 334
[3] H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR
BAX, A
SUMMERS, MF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) : 2093 - 2094
[4] SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY
BAX, A
SUBRAMANIAN, S
[J]. JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) : 565 - 569
[5] CARBON-HYDROGEN SPIN-SPIN COUPLING-CONSTANTS
HANSEN, PE
[J]. PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1981, 14 : 175 - 296
[6] APPLICATION OF PHASE SENSITIVE TWO-DIMENSIONAL CORRELATED SPECTROSCOPY (COSY) FOR MEASUREMENTS OF H-1-H-1 SPIN-SPIN COUPLING-CONSTANTS IN PROTEINS
MARION, D
WUTHRICH, K
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 113 (03) : 967 - 974
[7] Marshall J. L., 1983, CARBON CARBON CARBON, V2, P10
[8] NEUHAUS D, 1989, NUCLEAR OVERHAUSER E
[9] REACTIONS OF ARYLIDENETETRALONES WITH DERIVATES OF CYANOACETIC ACID - HETEROCYCLES BY MICHAEL REACTIONS IV
OTTO, HH
SCHMELZ, H
[J]. MONATSHEFTE FUR CHEMIE, 1979, 110 (02): : 249 - 256
[10] SYNTHESIS OF 4-ARYL-5,6-DIHYDRO-BENZO[H]QUINOLINES - HETEROCYCLES BY MICHAEL REACTIONS, .2.
OTTO, HH
RINUS, O
SCHMELZ, H
[J]. MONATSHEFTE FUR CHEMIE, 1979, 110 (01): : 115 - 119

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