THE TH1-TH2 HYPOTHESIS OF HIV-INFECTION - NEW INSIGHTS

被引：625

作者：

CLERICI, M ^{[1
]}

SHEARER, GM ^{[1
]}

机构：

[1] NCI, EXPTL IMMUNOL BRANCH, BETHESDA, MD 20892 USA

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 12期

关键词：

D O I：

10.1016/0167-5699(94)90220-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In their earlier, much quoted, viewpoint article, Mario Clerici and Gene Shearer examined the role of T helper 1 (Th1)- and Th2-type responses in immune dysregulation associated with human immunodeficiency virus (HIV) infection. In this article, they consider she complications of a Th1-Th2 model raised by the nomenclature, discuss the issue of cytokine production by non-T cells, and compare data obtained from T-cell clones with heterogeneous populations of leukocytes from patients. They define Th-cell responses and cytokine profiles as 'type 1' and 'type 2', and reemphasize the importance of strong cellular immune responses, along with the cytokines that augment and maintain such responses, in protective immunity against HIV infection and AIDS progression. Finally, they present a model of activation-induced, cytokine-modulated, programmed cell death as a major factor in the pathogenesis of HIV infection and AIDS.

引用

页码：575 / 581

页数：7

共 104 条

[1] HELMINTH INFECTION RESULTS IN DECREASED VIRUS-SPECIFIC CD8+ CYTOTOXIC T-CELL AND TH1-CYTOKINE RESPONSES AS WELL AS DELAYED VIRUS CLEARANCE [J].