SPECTROPHOTOMETRIC DETERMINATION OF DOMPERIDONE USING DELTA-A METHOD

被引：21

作者：

ALKHAMIS, KI ^{[1
]}

HAGGA, MEM ^{[1
]}

ALKHAMEES, HA ^{[1
]}

ALAWADI, M ^{[1
]}

机构：

[1] KING SAUD UNIV,COLL PHARM,DEPT PHARMACEUT CHEM,POB 2457,RIYADH 11451,SAUDI ARABIA

来源：

ANALYTICAL LETTERS | 1990年 / 23卷 / 03期

关键词：

AA-method; Domperidone determination; pharmaceutical analysis; spectrophotometry;

D O I：

10.1080/00032719008052456

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A spectrophotometric method for the assay of domperidone tablets (Motilium(R)-10 mg) is described. The mean percentage found for the active ingredient per tablet was 100.61 1.19. The drug exhibits maximum absorption at 282 nm in 0.5 N-sulphuric acid and at 294 nm in 0.5 N-sodium hydroxide due to keto-enol tautomerism, AA at 300 nm proved to be linearly related to the drug concentration in the range 5–30 pg ml-1 with a coefficient of variation 1.09%. %. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：451 / 460

页数：10