ATRIAL-NATRIURETIC-PEPTIDE AND BRAIN NATRIURETIC PEPTIDE COEXIST IN THE SECRETORY GRANULES OF HUMAN CARDIAC MYOCYTES

被引：93

作者：

NAKAMURA, S ^{[1
]}

NARUSE, M ^{[1
]}

NARUSE, K ^{[1
]}

KAWANA, M ^{[1
]}

NISHIKAWA, T ^{[1
]}

HOSODA, S ^{[1
]}

TANAKA, I ^{[1
]}

YOSHIMI, T ^{[1
]}

YOSHIHARA, I ^{[1
]}

INAGAMI, T ^{[1
]}

UEMURA, H ^{[1
]}

DEMURA, H ^{[1
]}

机构：

[1] KANAGAWA DENT COLL,BIOL LAB,YOKOSUKA,JAPAN

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 11期

关键词：

BRAIN NATRIURETIC PEPTIDE; ATRIAL NATRIURETIC PEPTIDE; SECRETORY GRANULE; HUMAN HEART;

D O I：

10.1093/ajh/4.11.909

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

To elucidate the intracellular localization of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in human cardiac myocytes, an immunocytochemical study was carried out by a double immunogold technique using antisera highly specific for ANP and BNP. Surgical and autopic tissue specimens of human heart were studied. In the atrial myocytes, ANP was localized in almost all of the secretory granules, whereas BNP was colocalized with ANP in some of the granules. Although very few secretory granules were observed in ventricular myocytes, colocalization of ANP and BNP was basically the same as in atrial myocytes. No immunoreactive products were found in the control studies. These results suggest that secretion of BNP is under a regulatory mechanism similar to that of ANP.

引用

页码：909 / 912

页数：4

共 15 条

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