ROLE OF SOMATOSTATIN AND ITS ANALOGS IN THE PATHOGENESIS AND TREATMENT OF DIABETES-MELLITUS

被引：16

作者：

GERICH, JE

机构：

[1] UNIV PITTSBURGH,SCH MED,CTR CLIN RES,DEPT MED,PITTSBURGH,PA 15261

[2] UNIV PITTSBURGH,SCH MED,CTR CLIN RES,DEPT PHYSIOL,PITTSBURGH,PA 15261

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 1990年 / 39卷 / 09期

关键词：

D O I：

10.1016/0026-0495(90)90211-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatostatin secreted by pancreatic D cells is a potent inhibitor of insulin, glucagon and growth hormone secretion, as well as other cells. The role of abnormal pancreatic D-cell function in diabetes mellitus is unclear. However, development of long-acting selective somatostatin analogs might prove useful in the treatment of diabetes. © 1990.

引用

收藏

页码：52 / 54

页数：3

相关论文

共 43 条

[1]

BAETENS D, 1978, DIABETES, V27, P1, DOI 10.2337/diabetes.27.1.1

[2] TEMPORAL RELATIONSHIP OF TISSUE SOMATOSTATIN-LIKE IMMUNOREACTIVITY TO METABOLIC CHANGES IN GENETICALLY-OBESE AND DIABETIC MICE [J].

BERELOWITZ, M ;

COLEMAN, DL ;

FROHMAN, LA .

DIABETES, 1980, 29 (09) :717-723

[3] PLASMA-IMMUNOREACTIVE SOMATOSTATIN IS ELEVATED IN DIABETIC-KETOACIDOSIS AND CORRELATES WITH PLASMA NONESTERIFIED FATTY-ACID CONCENTRATION [J].

BINIMELIS, J ;

WEBB, SM ;

SERRANO, J ;

CODINA, M ;

CORCOY, R ;

PEREZ, A ;

PEINADO, MA ;

PUIG, M ;

DELATORRE, W ;

SERRAT, J ;

GOMEZ, JA ;

CASAMITJANA, R ;

DELEIVA, A .

DIABETIC MEDICINE, 1987, 4 (03) :221-224

[4] SOMATOSTATIN RELEASE AND PLASMA MOLECULAR SOMATOSTATIN COMPONENTS IN MAN [J].

BURHOL, PG ;

LYGREN, I ;

JENSSEN, TG ;

FLORHOLMEN, J ;

JORDE, R .

ACTA PHYSIOLOGICA SCANDINAVICA, 1984, 121 (03) :223-228

[5] CIRCULATING SOMATOSTATIN CONCENTRATIONS IN HEALTHY AND NON-INSULIN-DEPENDENT (TYPE-II) DIABETIC SUBJECTS [J].

CONLON, JM ;

MCCULLOCH, AJ ;

ALBERTI, KGMM .

DIABETES, 1983, 32 (08) :723-729

[6]

DAVIES RR, 1989, DIABETIC MED, V6, P103

[7] SOMATOSTATIN IN THE PANCREAS AND HYPOTHALAMUS OF OBESE MICE [J].

DOLAISKITABGI, J ;

LEMARCHANDBRUSTEL, Y ;

FREYCHET, P .

DIABETOLOGIA, 1979, 17 (04) :257-261

[8]

GERICH J, 1987, SOMATOSTATIN BASIC C, P303

[9] CLINICAL EVALUATION OF SOMATOSTATIN AS A POTENTIAL ADJUNCT TO INSULIN IN MANAGEMENT OF DIABETES-MELLITUS [J].

GERICH, JE ;

SCHULTZ, TA ;

LEWIS, SB ;

KARAM, JH .

DIABETOLOGIA, 1977, 13 (05) :537-544

[10]

Gerich JE, 1981, HDB DIABETES MELLITU, V1, P297

← 1 2 3 4 5 →