CHANGES IN THYROID-HORMONES, THYROID STIMULATING HORMONE AND CORTISOL IN ACUTE SPINAL-CORD INJURY

被引：11

作者：

BUGARESTI, JM ^{[1
]}

TATOR, CH ^{[1
]}

SILVERBERG, JD ^{[1
]}

SZALAI, JP ^{[1
]}

MALKIN, DG ^{[1
]}

MALKIN, A ^{[1
]}

TAY, SK ^{[1
]}

机构：

[1] UNIV TORONTO,TORONTO WESTERN HOSP,SPINAL CORD INJURY TREATMENT RES & PREVENT CTR,ROOM 2002,TORONTO M5T 2S8,ONTARIO,CANADA

来源：

PARAPLEGIA | 1992年 / 30卷 / 06期

关键词：

THYROID HORMONES; CORTISOL; ACUTE SPINAL CORD INJURY; METABOLIC RESPONSE TO INJURY;

D O I：

10.1038/sc.1992.90

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To determine the hormonal response to acute spinal cord injury, serial serum samples were collected from 18 patients with acute spinal cord injury and from 14 control patients with spinal fractures without cord injury. The first sample was taken within 24 hours of injury, the second at 24-48 hours; and the third at 7 days for determination of thyroxine (T4), free T4 (FT4), triiodothyronine (T3), reverse T3 (rT3), T3 uptake (T3U), thyroid stimulating hormone (TSH), thyroxine binding globulin (TBG), growth hormone (GH), cortisol, and insulin. Significant increases were observed in rT3 levels and transient changes were observed in the T4 and T3 levels in the spinal cord injured group but not in the group with spinal fractures alone. The changes in the spinal cord injured patients are consistent with the 'low T3 syndrome'. However, the persisting rise of rT3 at 7 days was an unexpected finding. In addition to the cord injury, these changes may also be related to dexamthasone administration and nutritional factors.

引用

页码：401 / 409

页数：9

共 24 条

[1]

Keirnan J.A., Hypotheses concerned with regeneration of the mammalian nervous system, Biol Rev, 54, pp. 155-197, (1979)

[2]

Cook R.A., Keirnan J.A., Effects of triiodothyronine on protein synthesis in regenerating peripheral neurons, Exp Neurol, 52, pp. 515-524, (1976)

[3]

Harvey J.E., Srebnik H.H., Locomotor activity and axon regeneration following spinal cord compression in rats treated with L-thyroxine, J Neuropathol Exp Neurol, 26, pp. 661-668, (1967)

[4]

Tator C.H., Van Der Jagt R., The effect of exogenous thyroid hormones on functional recovery of the rat after acute spinal cord compression injury, J Neurosurg, 53, pp. 381-384, (1980)

[5]

Tator C.H., Rivlin A.S., Lewis A.J., Schmoll B., Effect of triiodo-L-thronine on axonal regeneration in the rat spinal cord after acute compression injury, J Neurosurg, 58, pp. 406-409, (1983)

[6]

Faden A.I., Jacobs T.P., Smith T.M., Thyrotropin-releasing hormone in experimental cord injury: Dose response and late treatment, Neurology (Cleveland), 34, pp. 1280-1284, (1984)

[7]

Faden A.I., Jacob T.P., Effect of TRH analogs on neurologic recovery after experimental spinal trauma, Neurology, 35, pp. 1331-1334, (1985)

[8]

Faden A.I., Vink R., McIntosh T.K., Thyrotropin-releasing hormone and central nervous system trauma, Ann NY Acad Sci, 553, pp. 380-384, (1989)

[9]

Claus-Walker J., Vallbona C., Carter R.E., Lipscomb H.S., Resting and stimulated endocrine function in human subjects with cervical cord transection, J Chron Dis, 24, pp. 193-207, (1971)

[10]

Claus-Walker J., Halstead L.S., Carter R.E., Campos R.J., Spencer W.A., Biochemical responses to intense local cooling in healthy subjects and in subjects with cervical spinal cord injury, Arch Phys Med Rehabii, 57, pp. 50-54, (1976)

← 1 2 3 →