ANATOMY OF AN ENHANCER

被引：84

作者：

THOMPSON, CC

MCKNIGHT, SL

机构：

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 07期

关键词：

D O I：

10.1016/0168-9525(92)90121-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Enhancers, the elements that regulate spatial and temporal gene expression in eukaryotic cells, act as templates for the assembly of multiprotein complexes. Studies on the enhancers associated with immediate-early genes of herpes simplex virus reveal an unanticipated recurrence of specific protein-protein interactions, comparable to a three-dimensional 'jigsaw' puzzle. The arrangement of cis regulatory motifs - the DNA sequence of an enhancer - forms the puzzle template. Specific regulatory proteins, by forming contours of appropriate fit for both DNA template and neighboring proteins, constitute the puzzle pieces.

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页码：232 / 236

页数：5

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