CORRELATION BETWEEN THE INDUCTION OF AN IMMEDIATE EARLY GENE, ZIF 268, AND LONG-TERM POTENTIATION IN THE DENTATE GYRUS

被引：134

作者：

RICHARDSON, CL

TATE, WP

MASON, SE

LAWLOR, PA

DRAGUNOW, M

ABRAHAM, WC

机构：

[1] UNIV OTAGO,DEPT PSYCHOL,BOX 56,DUNEDIN,NEW ZEALAND

[2] UNIV OTAGO,DEPT BIOCHEM,DUNEDIN,NEW ZEALAND

[3] UNIV OTAGO,NEUROSCI RES CTR,DUNEDIN,NEW ZEALAND

[4] UNIV AUCKLAND,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL,AUCKLAND,NEW ZEALAND

来源：

BRAIN RESEARCH | 1992年 / 580卷 / 1-2期

关键词：

IMMEDIATE EARLY GENE; LONG-TERM POTENTIATION; DENTATE GYRUS; IMMUNOHISTOCHEMISTRY; NORTHERN BLOT; AWAKE RAT;

D O I：

10.1016/0006-8993(92)90938-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Expression of the immediate early gene zif/268 (also termed NGFI-A, Krox 24, TIS8 and Egr-1) was investigated in awake rats following various long-term potentiation (LTP) induction protocols. zif/268 mRNA (Northern blots) and protein (immunohistochemistry) levels sharply increased following LTP, and followed a time course characteristic of other immediate early genes. When measured across 3 tetanization protocols known to produce differing degrees of LTP persistence, zif/268 induction was found to be more highly correlated with LTP duration than with the magnitude of initial LTP. These data support the hypothesis that the immediate early gene zif/268 plays a role as a third messenger in the cascade of cellular and nuclear events that govern the persistence of LTP.

引用

页码：147 / 154

页数：8

共 36 条

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