PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

被引：34

作者：

HOWARTH, NM

COOPER, G

PUROHIT, A

DUNCAN, L

REED, MJ

POTTER, BVL

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,BATH BA2 7AY,AVON,ENGLAND

[2] IMPERIAL COLL SCI TECHNOL & MED,ST MARYS HOSP,SCH MED,METAB MED UNIT,LONDON W2 1PG,ENGLAND

[3] UNIV BATH,INST LIFE SCI,BATH BA2 7AY,AVON,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80900-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

引用

页码：313 / 318

页数：6

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