BASIC FIBROBLAST GROWTH-FACTOR OPENS CALCIUM-PERMEABLE CHANNELS IN QUAIL MESENCEPHALIC NEURAL CREST NEURONS

被引：16

作者：

DISTASI, C

MUNARON, L

LAEZZA, F

LOVISOLO, D

机构：

[1] Dipartimento di Biologia Animale, Laboratorio di Fisiologia Generale, Torino, I-10123

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 1995年 / 7卷 / 03期

关键词：

CALCIUM INFLUX; CYTOSOLIC CALCIUM INCREASE; NEURONAL DEVELOPMENT;

D O I：

10.1111/j.1460-9568.1995.tb00348.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to investigate the action of basic fibroblast growth factor (bFGF) in the nervous system, we have studied the ionic signals elicited by this peptide in cultured quail mesencephalic neural crest neurons using patch-clamp and cytofluorimetric techniques. In this preparation stimulation with bFGF induced, with a delay of some tens of seconds, an inward cationic current. Single-channel experiments provided evidence for the activation of a calcium-permeable channel. In single-cell cytofluorimetric measurements, a sustained rise in [Ca2+](i) was observed, which was dependent on the presence of external calcium. These events may play a role in the developmental effects of bFGF.

引用

页码：516 / 520

页数：5

共 29 条

[1] THE CA SIGNAL FROM FURA-2 LOADED MAST-CELLS DEPENDS STRONGLY ON THE METHOD OF DYE-LOADING [J].