NONPARAMETRIC BAYESIAN BIOASSAY WITH PRIOR CONSTRAINTS ON THE SHAPE OF THE POTENCY CURVE

被引：26

作者：

RAMGOPAL, P

LAUD, PW

SMITH, AFM

机构：

[1] NO ILLINOIS UNIV,DIV STAT,DE KALB,IL 60115

[2] IMPERIAL COLL SCI TECHNOL & MED,DEPT MATH,LONDON SW7 2BZ,ENGLAND

来源：

BIOMETRIKA | 1993年 / 80卷 / 03期

关键词：

BIOASSAY; CONCAVE; CONVEX; DIRICHLET DISTRIBUTION; GIBBS SAMPLING; HAZARD RATES; IMPORTANCE RESAMPLING; POTENCY CURVE;

D O I：

10.1093/biomet/80.3.489

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We consider the problem of implementing nonparametric Bayesian analysis of bioassay problems when the prior constrains the form of the potency curve (for example, to be convex, concave or ogive). Sampling based approaches to calculating posterior features of interest are detailed and illustrated. Extensions to prior constraints on hazard rates are outlined.

引用

页码：489 / 498

页数：10

共 8 条

[1]

Cox D.R., 1989, ANAL BINARY DATA

[2]

Devroye L., 1986, NONUNIFORM RANDOM VA

[3]

GELFAND AE, 1991, BIOMETRIKA, V78, P657

[4] SAMPLING-BASED APPROACHES TO CALCULATING MARGINAL DENSITIES [J].