PEFLOXACIN CLINICAL PHARMACOKINETICS

被引:20
作者
BRESSOLLE, F
GONCALVES, F
GOUBY, A
GALTIER, M
机构
[1] CHU CAREMEAU, PHARMACOCINET LAB, NIMES, FRANCE
[2] CHU G DOUMERGUE, BACTERIOL LAB, NIMES, FRANCE
关键词
D O I
10.2165/00003088-199427060-00003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pefloxacin has a broad spectrum of activity against a great number of Gramnegative and Gram-positive bacteria. It is also capable of penetration into cells, yielding high tissue : serum ratios, with implications for the treatment of infections caused by intracellular pathogens. Pefloxacin is well absorbed from the gastrointestinal tract. Its elimination half-life ranges from 6.2 to 12.4 hours. After repeated administration, a major change in pharmacokinetic parameters is observed. Pharmacokinetic parameters are minimally altered or not altered in patients with impaired renal function. Altered plasma pharmacokinetics in patients with liver insufficiency and in elderly patients are observed, so dosage adjustments are necessary. In addition, pefloxacin interacts with a number of other compounds at hepatic (e.g. theophylline and cimetidine) and gastrointestinal (e.g. antacids) sites. With the exception of saliva, cerebrospinal fluid, aqueous humor, vitreous fluid and amniotic fluid, body fluid concentrations reach plasma concentrations. Studies on tissue penetration show that concentrations exceeding plasma concentrations are obtained in most tissues. The highest tissue : plasma concentration ratios are achieved in lung and kidney, whereas concentrations in fat are considerably lower than those in plasma.
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收藏
页码:418 / 446
页数:29
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