EXCLUSION OF LINKAGE OF SCHIZOPHRENIA TO THE GENE FOR THE DOPAMINE D2 RECEPTOR (DRD2) AND CHROMOSOME 11Q TRANSLOCATION SITES

被引：18

作者：

KALSI, G

MANKOO, BS

CURTIS, D

BRYNJOLFSSON, J

READ, T

SHARMA, T

MURPHY, P

PETURSSON, H

GURLING, HMD

机构：

[1] INST PSYCHIAT,GENET SECT,LONDON SE5 8AF,ENGLAND

[2] UNIV COLL & MIDDLESEX SCH MED,ACAD DEPT PSYCHIAT,MOLEC PSYCHIAT LAB,LONDON,ENGLAND

[3] UNIV ICELAND,DEPT PSYCHIAT,REYKJAVIK,ICELAND

来源：

PSYCHOLOGICAL MEDICINE | 1995年 / 25卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1017/S0033291700033456

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

There have been previous reports of a 1q43;11q21 translocation cosegregating with schizophrenia and a 9p22;11q22.3 translocation cosegregating with manic depression. In addition, the genes for the dopamine D2 receptor and for tyrosinase both map to chromosome 11q. Three 11q DNA markers were used to investigate 23 pedigrees containing multiple cases of schizophrenia. Strongly negative led scores were obtained, providing evidence against linkage over a 70 cM region which included both translocation sites and both candidate genes.

引用

页码：531 / 537

页数：7

共 37 条

[1] ASSOCIATION OF DOPAMINE D2 RECEPTOR MOLECULAR VARIANT WITH SCHIZOPHRENIA [J].