PEROXIDATION OF THE DRIED THIN-FILM OF LIPID BY HIGH-ENERGY ALPHA-PARTICLES FROM A CYCLOTRON

被引：9

作者：

AGARWAL, S ^{[1
]}

CHATTERJEE, SN ^{[1
]}

机构：

[1] SAHA INST NUCL PHYS, DIV BIOPHYS, 37 BELGACHIA RD, CALCUTTA 700037, INDIA

来源：

RADIATION RESEARCH | 1984年 / 100卷 / 02期

关键词：

D O I：

10.2307/3576346

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High-energy .alpha. particles produced a dose-dependent linear increase in different lipid peroxidation products (e.g., malondialdehyde (MDA), conjugated dienes, and hydroperoxides) in the dried thin film state. An inverse dose-rate effect was observed when the dose rate was varied by changing either the .alpha.-particle fluence rate or the .alpha.-particle energy. The antioxidants .alpha.-tocopherol and butylated hydroxytoluene (BHT) suppressed the .alpha.-particle-induced lipid peroxidation in the dried thin film state, and in this respect .alpha.-tocopherol was found superior to BHT. .alpha.-Tocopherol was equally efficient in inhibiting lipid peroxidations by .alpha. particles and UV light.

引用

页码：257 / 263

页数：7

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