ZINC CITRATE TRICLOSAN - A NEW ANTI-PLAQUE SYSTEM FOR THE CONTROL OF PLAQUE AND THE PREVENTION OF GINGIVITIS - SHORT-TERM CLINICAL AND MODE OF ACTION STUDIES

被引:60
作者
CUMMINS, D
机构
[1] Unilever Dental Research, Port Sunlight Laboratory, Bebington, L63 3JW, Quarry Road East
关键词
ZINC CITRATE; TRICLOSAN; PLAQUE GINGIVITIS; CLINICAL; MICROBIOLOGICAL; PHARMACOKINETICS;
D O I
10.1111/j.1600-051X.1991.tb02316.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
A dentifrice based upon the additive anti-plaque effects of zinc citrate and Triclosan has been developed and optimised for clinical activity. In 16-h and 4-day plaque growth inhibition studies, zinc citrate/Triclosan inhibited plaque accumulation significantly more than either agent alone. The effect on the development of gingivitis has been demonstrated in a 21-day experimental gingivitis study. ZCT/Triclosan reduced the development of gingival bleeding sites by significantly more than ZCT alone, suggesting that the system has the potential to give a gingival health benefit in a 6-month unsupervised brushing study. Zinc and Triclosan employ multiple modes of antimicrobial action and these result in reduced growth, inhibition of glucose uptake and metabolism and modified virulence of periodontal pathogens. Importantly, the effects of zinc and Triclosan are additive and complementary. Oral substantivity is a pre-requisite of any agent for anti-plaque activity in vivo. Pharmacokinetic data demonstrate that approximately 30% of the zinc and Triclosan dosed is retained immediately after brushing. Saliva decay curves indicate that Triclosan is cleared more quickly from the mouth than zinc, consistent with the physicochemical properties of these agents. Triclosan is present in plaque for at least 8 h and in the oral mucosa for at least 3 h after brushing.
引用
收藏
页码:455 / 461
页数:7
相关论文
共 44 条
[1]   EFFECT OF TOOTHPASTE RINSES COMPARED WITH CHLORHEXIDINE ON PLAQUE-FORMATION DURING A 4-DAY PERIOD [J].
ADDY, M ;
WILLIS, L ;
MORAN, J .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1983, 10 (01) :89-99
[2]  
Ciancio S G, 1989, Am J Dent, V2 Spec No, P299
[3]  
CUMMINS D, 1989, J DENT RES, V68, P1702
[4]  
CUMMINS D, 1989, S E ASIA IADR
[5]  
GILBERT RJ, 1989, J DENT RES, V68, P1706
[7]   THE ORAL RETENTION AND ANTIPLAQUE EFFICACY OF TRICLOSAN IN HUMAN VOLUNTEERS [J].
GILBERT, RJ ;
WILLIAMS, PEO .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 23 (05) :579-583
[8]   ORAL DISPOSITION OF TRICLOSAN (2,4,4'-TRICHLORO-2'-HYDROXYDIPHENYL ETHER) DELIVERED FROM A DENTIFRICE [J].
GILBERT, RJ ;
FRASER, SB ;
VANDEROUDERAA, FJG .
CARIES RESEARCH, 1987, 21 (01) :29-36
[9]  
GILBERT RJ, 1986, J DENTAL RES, V65
[10]  
GJERMO P, 1989, J DENT RES, V68, P1602