THE REGULATION OF CATALYSIS IN ATP SYNTHASE

被引:92
作者
WALKER, JE
机构
[1] Medical Research Council Laboratory of Molecular Biology, Cambridge
关键词
D O I
10.1016/0959-440X(94)90274-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
ATP synthase is regulated so as to prevent futile hydrolysis of ATP when the transmembrane proton electrochemical gradient, Delta mu(H)(+), falls. Mitochondria and chloroplasts have different mechanisms for inhibition of ATP synthase: by binding an inhibitor protein, and by stabilization of the ADP-inhibited state by making an intramolecular disulphide bond, respectively. The recently determined structure of bovine F-1-ATPase is locked in a conformation that probably represents the ADP-inhibited state of the enzyme.
引用
收藏
页码:912 / 918
页数:7
相关论文
共 52 条
  • [1] STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA
    ABRAHAMS, JP
    LESLIE, AGW
    LUTTER, R
    WALKER, JE
    [J]. NATURE, 1994, 370 (6491) : 621 - 628
  • [2] AGGELER R, 1993, J BIOL CHEM, V268, P14576
  • [3] FUNCTIONAL SITES IN F1-ATPASES - LOCATION AND INTERACTIONS
    ALLISON, WS
    JAULT, JM
    ZHUO, SQ
    PAIK, SR
    [J]. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1992, 24 (05) : 469 - 477
  • [4] IMMUNOLOGICAL STUDIES ON THE BEEF-HEART NATURAL ATPASE INHIBITORS - LOCALIZATION OF AN ANTIGENIC DETERMINANT IN THE INHIBITOR MOLECULE
    AUDINET, C
    DIANOUX, AC
    VIGNAIS, PV
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 137 (01) : 364 - 371
  • [5] THE EFFECT OF SULFITE ON THE ATP HYDROLYSIS AND SYNTHESIS ACTIVITY OF MEMBRANE-BOUND H+-ATP SYNTHASE FROM VARIOUS SPECIES
    BAKELS, RHA
    VANWALRAVEN, HS
    VANWIELINK, JE
    VANDERZWETDEGRAAFF, I
    KRENN, BE
    KRAB, K
    BERDEN, JA
    KRAAYENHOF, R
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 201 (02) : 487 - 492
  • [6] THE BINDING CHANGE MECHANISM FOR ATP SYNTHASE - SOME PROBABILITIES AND POSSIBILITIES
    BOYER, PD
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1140 (03) : 215 - 250
  • [7] INHIBITION OF THE BOVINE-HEART MITOCHONDRIAL F1-ATPASE BY CATIONIC DYES AND AMPHIPATHIC PEPTIDES
    BULLOUGH, DA
    CECCARELLI, EA
    ROISE, D
    ALLISON, WS
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 975 (03) : 377 - 383
  • [8] BULLOUGH DA, 1989, J BIOL CHEM, V264, P9155
  • [9] COUPLING BETWEEN CATALYTIC SITES AND THE PROTON CHANNEL IN F1F0-TYPE ATPASES
    CAPALDI, RA
    AGGELER, R
    TURINA, P
    WILKENS, S
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1994, 19 (07) : 284 - 289
  • [10] CHERNYAK BV, 1986, TRENDS BIOCHEM SCI, V11, P32, DOI 10.1016/0968-0004(86)90229-X