HUMAN PAPILLOMAVIRUS TYPE-6 IN GRADE-I TRANSITIONAL CELL-CARCINOMA OF THE URETHRA

被引:39
作者
MEVORACH, RA
COS, LR
DISANTAGNESE, PA
STOLER, M
机构
[1] UNIV ROCHESTER,SCH MED & DENT,DEPT UROL,ROCHESTER,NY 14642
[2] UNIV ROCHESTER,SCH MED & DENT,DEPT PATHOL,ROCHESTER,NY 14642
[3] UNIV ROCHESTER,SCH MED & DENT,DEPT LAB MED,ROCHESTER,NY 14642
关键词
D O I
10.1016/S0022-5347(17)39888-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Of 4 patients who underwent cystourethroscopy, biopsy and laser excision of suspected urethral condylomata acuminata 3 had coexistent grade I papillary transitional cell carcinoma of the urethra. Human papillomavirus type 6 messenger ribonucleic acid was demonstrated within biopsy specimens using tritium-labeled single-stranded antisense ribonucleic acid probes. Compared to condylomata the papillary transitional epithelium expressed less viral message, which might be expected in an epithelium that does not show full squamous epithelial or koilocytotic differentiation. Among these patients there was 1 papillary transitional lesion in the bladder that, although histologically similar, did not express human papillomavirus message, suggesting differential susceptibility of epithelium between the bladder and urethra. The finding of active human papillomavirus transcription within the urethral papillary transitional lesions raises the possibility of an active role for the virus in the pathogenesis of these lesions. These findings broaden the spectrum of epithelial types reported to support human papillomaviruses and provides impetus for a wider search for these viruses in other transitional cell neoplasms.
引用
收藏
页码:126 / 128
页数:3
相关论文
共 13 条
[1]   DEMONSTRATION OF PAPILLOMAVIRUS STRUCTURAL ANTIGEN IN HUMAN URINARY-BLADDER NEOPLASIA [J].
BRYANT, P ;
SKELLY, J ;
WILSON, D .
BRITISH JOURNAL OF UROLOGY, 1987, 60 (05) :405-409
[2]   HUMAN PAPILLOMAVIRUS STRUCTURAL ANTIGENS IN SQUAMOUS PAPILLOMAS OF THE MALE URETHRA [J].
DEAN, P ;
LANCASTER, WD ;
CHUN, B ;
JENSON, AB .
JOURNAL OF UROLOGY, 1983, 129 (04) :873-875
[3]   IDENTIFICATION OF HUMAN PAPILLOMAVIRUS TYPES IN MALE URETHRAL CONDYLOMATA ACUMINATA BY INSITU HYBRIDIZATION [J].
DELMISTRO, A ;
BRAUNSTEIN, JD ;
HALWER, M ;
KOSS, LG .
HUMAN PATHOLOGY, 1987, 18 (09) :936-940
[4]   HUMAN PAPILLOMAVIRUS TYPE-6 AND TYPE-11 DNA-SEQUENCES IN GENITAL AND LARYNGEAL PAPILLOMAS AND IN SOME CERVICAL CANCERS [J].
GISSMANN, L ;
WOLNIK, L ;
IKENBERG, H ;
KOLDOVSKY, U ;
SCHNURCH, HG ;
ZURHAUSEN, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (02) :560-563
[5]   PAPILLOMAVIRUS INFECTION OF THE ANOGENITAL REGION - CORRELATION BETWEEN HISTOLOGY, CLINICAL PICTURE, AND VIRUS TYPE - PROPOSAL OF A NEW NOMENCLATURE [J].
GROSS, G ;
IKENBERG, H ;
GISSMANN, L ;
HAGEDORN, M .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1985, 85 (02) :147-152
[6]  
GRUSSENDORFCONEN EI, 1987, CANCER, V60, P1832, DOI 10.1002/1097-0142(19871015)60:8<1832::AID-CNCR2820600826>3.0.CO
[7]  
2-2
[8]   SUSCEPTIBILITY OF VARIOUS HUMAN-TISSUES TO TRANSFORMATION INVIVO WITH HUMAN PAPILLOMAVIRUS TYPE-11 [J].
KREIDER, JW ;
HOWETT, MK ;
STOLER, MH ;
ZAINO, RJ ;
WELSH, P .
INTERNATIONAL JOURNAL OF CANCER, 1987, 39 (04) :459-465
[9]   CONDYLOMA ACUMINATUM OF THE BLADDER AND ASSOCIATED UROTHELIAL MALIGNANCY [J].
LIBBY, JM ;
FRANKEL, JM ;
SCARDINO, PT .
JOURNAL OF UROLOGY, 1985, 134 (01) :134-136
[10]  
ORIEL JD, 1971, BRIT J VENER DIS, V47, P1