EFFECT OF TRICYCLIC ANTIDEPRESSANT DRUGS ON LYMPHOCYTE MEMBRANE-STRUCTURE

被引：13

作者：

AUDUS, KL ^{[1
]}

GORDON, MA ^{[1
]}

机构：

[1] UNIV KANSAS HOSP, KANSAS CITY, KS 66103 USA

来源：

JOURNAL OF IMMUNOPHARMACOLOGY | 1984年 / 6卷 / 1-2期

关键词：

D O I：

10.3109/08923978409026463

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tricyclic antidepressant[desipramine, nortriptyline, protriptyline and imipramine]-induced perturbations of murine splenic lymphocyte membranes and cell surface concanavalin A receptor mobility were investigated using the fluorescent probes diphenylhexatriene and fluorescein-conjugated concanavalin A. The possible relationship between tricyclic antidepressant-induced membrane perturbations and tricyclic antidepressant-induced suppression of the normal murine lymphocyte mitogen response was shown. Tricyclic antidepressant effects on murine splenic lymphocyte membranes are dose-, time- and temperature-dependent. Murine lymphocyte concanavalin A cell surface receptor mobility is not apparently altered by the tricyclic antidepressants.

引用

页码：105 / 132

页数：28

共 48 条

[1] TEMPERATURE-DEPENDENCE OF 1,6-DIPHENYL-1,3,5-HEXATRIENE FLUORESCENCE IN PHOSPHOLIPID ARTIFICIAL MEMBRANES [J].