THE INFLUENCE OF AREA OF APPLICATION ON SENSITIZATION BY DINITROCHLOROBENZENE

被引：41

作者：

REES, JL ^{[1
]}

FRIEDMANN, PS ^{[1
]}

MATTHEWS, JNS ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT DERMATOL,NEWCASTLE TYNE NE1 4LP,ENGLAND

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1990年 / 122卷 / 01期

关键词：

D O I：

10.1111/j.1365-2133.1990.tb08236.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

We have investigated the effect on sensitization of altering the area of application of 2,4,dinitrochlorobenzene (DNCB) at a constant dose per unit area. We showed that, when an area of less than 1 cm2 is used, this area is critical in determining the degree of sensitization. This contrasts with previous work that showed, for larger areas, an alteration in the area of application had little effect on sensitization, whereas keeping the area constant and increasing the concentration of DNCB increased the degree of sensitization. We suggest that not only is the amount of antigen important in determining response, but also the distribution of the antigen as presented to the afferent limb of the immune system.

引用

页码：29 / 31

页数：3

共 5 条

[1]

FRIEDMANN PS, 1983, CLIN EXP IMMUNOL, V53, P709

[2]

MACATONIA SE, 1986, IMMUNOLOGY, V59, P509

[3]

MOSS C, 1985, CLIN EXP IMMUNOL, V61, P232

[4] SEX-DIFFERENCES IN SUSCEPTIBILITY TO DEVELOPMENT OF CONTACT HYPERSENSITIVITY TO DINITROCHLOROBENZENE (DNCB) [J].

REES, JL ;

FRIEDMANN, PS ;

MATTHEWS, JNS .

BRITISH JOURNAL OF DERMATOLOGY, 1989, 120 (03) :371-374

[5] THE EFFECT OF ALTERING AREA OF APPLICATION AND DOSE PER UNIT AREA ON SENSITIZATION BY DNCB [J].

WHITE, SI ;

FRIEDMANN, PS ;

MOSS, C ;

SIMPSON, JM .

BRITISH JOURNAL OF DERMATOLOGY, 1986, 115 (06) :663-668

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