STRUCTURE OF THE MOUSE TYROSINE-HYDROXYLASE GENE

被引:43
作者
IWATA, N
KOBAYASHI, K
SASAOKA, T
HIDAKA, H
NAGATSU, T
机构
[1] FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,TOYOAKE 47011,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT PHARMACOL,NAGOYA,AICHI 466,JAPAN
[3] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
关键词
D O I
10.1016/S0006-291X(05)80151-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The mouse tyrosine hydroxylase (TH) gene was isolated from a genomic library by cross-hybridization with human TH cDNA probe. Nucleotide sequence analysis of two overlapping genomic clones showed that this gene is split into 13 exons distributed about 7.5 kb in length. The transcription initiation site was determined by primer extension analysis with mouse adrenal gland poly(A)+RNA. The structure of the mouse TH gene was similar to that of the human TH gene, but it contained neither the alternative splice donor site around the 3′-end of the first exon nor an independent exon corresponding to the second exon of the human TH gene. There were the canonical TATA and GC boxes, cyclic AMP responsive element (CRE), and AP1 binding site in the 5′-flanking region of the mouse TH gene. © 1992 Academic Press, Inc.
引用
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页码:348 / 354
页数:7
相关论文
共 24 条
[1]  
BREATHNACH R, 1981, ANNU REV BIOCHEM, V50, P349, DOI 10.1146/annurev.bi.50.070181.002025
[2]   MURINE TYROSINE-HYDROXYLASE MAPS TO THE DISTAL END OF CHROMOSOME-7 WITHIN A REGION CONSERVED IN MOUSE AND MAN [J].
BRILLIANT, MH ;
NIEMANN, MM ;
EICHER, EM .
JOURNAL OF NEUROGENETICS, 1987, 4 (05) :259-266
[3]   5' FLANKING DNA-SEQUENCES DIRECT CELL-SPECIFIC EXPRESSION OF RAT TYROSINE-HYDROXYLASE [J].
CAMBI, F ;
FUNG, B ;
CHIKARAISHI, D .
JOURNAL OF NEUROCHEMISTRY, 1989, 53 (05) :1656-1659
[4]   SPECIES AND REGIONAL DIFFERENCES IN THE EXPRESSION OF CELL-TYPE SPECIFIC ELEMENTS AT THE HUMAN AND RAT TYROSINE-HYDROXYLASE GENE LOCI [J].
GANDELMAN, KY ;
COKER, GT ;
MOFFAT, M ;
OMALLEY, KL .
JOURNAL OF NEUROCHEMISTRY, 1990, 55 (06) :2149-2152
[5]  
GIZANGGINSBERG E, 1990, GENE DEV, V4, P447
[6]   A SINGLE HUMAN-GENE ENCODING MULTIPLE TYROSINE HYDROXYLASES WITH DIFFERENT PREDICTED FUNCTIONAL-CHARACTERISTICS [J].
GRIMA, B ;
LAMOUROUX, A ;
BONI, C ;
JULIEN, JF ;
JAVOYAGID, F ;
MALLET, J .
NATURE, 1987, 326 (6114) :707-711
[7]   PRIMARY STRUCTURE OF MOUSE TYROSINE-HYDROXYLASE DEDUCED FROM ITS CDNA [J].
ICHIKAWA, S ;
SASAOKA, T ;
NAGATSU, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 176 (03) :1610-1616
[8]  
KANEDA KJ, 1991, NEURON, V6, P583
[9]   ISOLATION OF A NOVEL CDNA CLONE FOR HUMAN TYROSINE-HYDROXYLASE - ALTERNATIVE RNA SPLICING PRODUCES 4 KINDS OF MESSENGER-RNA FROM A SINGLE GENE [J].
KANEDA, N ;
KOBAYASHI, K ;
ICHINOSE, H ;
KISHI, F ;
NAKAZAWA, A ;
KUROSAWA, Y ;
FUJITA, K ;
NAGATSU, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 146 (03) :971-975
[10]   STRUCTURE OF THE HUMAN TYROSINE-HYDROXYLASE GENE - ALTERNATIVE SPLICING FROM A SINGLE GENE ACCOUNTS FOR GENERATION OF 4 MESSENGER-RNA TYPES [J].
KOBAYASHI, K ;
KANEDA, N ;
ICHINOSE, H ;
KISHI, F ;
NAKAZAWA, A ;
KUROSAWA, Y ;
FUJITA, K ;
NAGATSU, T .
JOURNAL OF BIOCHEMISTRY, 1988, 103 (06) :907-912