SYNTHESIS OF THYMIDINE FROM 5-IODO-2'-DEOXYURIDINE

被引：25

作者：

HERDEWIJN, P

KERREMANS, L

WIGERINCK, P

VANDENDRIESSCHE, F

VANAERSCHOT, A

机构：

[1] Rega Institute for Medical Research, Division of Pharmaceutical Chemistry, Katholieke Universiteit Leuven, B-3000 Leuven

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)92180-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple, high yield synthesis of thymidine from 5-iodo-2'-deoxyuridine is described, using tetramethyltin and tetrakis(triphenylphosphine)palladium(0) in hexamethylphoshoric triamide. Likewise, 5-phenyl- and 5-vinyl-2'-deoxyuridine can be obtained, and through reduction of the latter the 5-ethyl analogue is also at hand.

引用

页码：4397 / 4400

页数：4

共 14 条

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