SYNTHESIS OF THYMIDINE FROM 5-IODO-2'-DEOXYURIDINE

被引:25
作者
HERDEWIJN, P
KERREMANS, L
WIGERINCK, P
VANDENDRIESSCHE, F
VANAERSCHOT, A
机构
[1] Rega Institute for Medical Research, Division of Pharmaceutical Chemistry, Katholieke Universiteit Leuven, B-3000 Leuven
关键词
D O I
10.1016/S0040-4039(00)92180-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple, high yield synthesis of thymidine from 5-iodo-2'-deoxyuridine is described, using tetramethyltin and tetrakis(triphenylphosphine)palladium(0) in hexamethylphoshoric triamide. Likewise, 5-phenyl- and 5-vinyl-2'-deoxyuridine can be obtained, and through reduction of the latter the 5-ethyl analogue is also at hand.
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页码:4397 / 4400
页数:4
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