RENAL DENERVATION DOES NOT PREVENT HYPERTENSION IN LYON HYPERTENSIVE RATS

被引：10

作者：

BOUSSAIRI, EH ^{[1
]}

JULIEN, C ^{[1
]}

DUCHER, M ^{[1
]}

BARRES, C ^{[1
]}

VINCENT, M ^{[1
]}

SASSARD, J ^{[1
]}

机构：

[1] FAC PHARM LYON,DEPT PHYSIOL & PHARMACOL CLIN,CNRS,URA 606,8 AVE ROCKEFELLER,F-69008 LYONS,FRANCE

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 261卷 / 01期

关键词：

ANGIOTENSIN-CONVERTING ENZYME INHIBITION; CATECHOLAMINES; DIRECT BLOOD PRESSURE RECORDING; GANGLIONIC BLOCKADE; BLOOD-PRESSURE; URINARY CATECHOLAMINES; SYMPATHECTOMIZED RATS; CONSCIOUS RATS; NERVES; SENSITIVITY; MAINTENANCE; STRAIN;

D O I：

10.1152/ajpregu.1991.261.1.R20

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects on blood pressure (BP) of a single and repeated renal denervations (RD) were compared in genetically hypertensive (LH) and normotensive (LN) rats of the Lyon strain. Indirect BP was measured by the tail-cuff method, and direct BP was measured through an aortic catheter in conscious quiet rats receiving a normal-sodium diet. Single RD (10 wk of age) did not reduce BP in both LN and LH rats. Repeated RD (4, 7, and 10 wk of age) partly prevented the age-related increase in tail-cuff BP but did not affect the directly recorded BP in 11-wk-old LH rats. Single and repeated RD reduced the renal norepinephrine content by > 90%. Both procedures did not alter the BP lowering effects of angiotensin-converting enzyme inhibition and of ganglionic blockade. It is concluded that renal nerves are not necessary for the development and the maintenance of hypertension in LH rats.

引用

页码：R20 / R25

页数：6

共 29 条

[1] ANTIHYPERTENSIVE EFFECTS OF S9490-3, A NEW CONVERTING-ENZYME-INHIBITOR, IN THE CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RAT [J].

BARRES, C ;

CERUTTI, C ;

PAULTRE, CZ ;

SASSARD, J .

CLINICAL SCIENCE, 1986, 70 (02) :167-175

[2] EFFECTS OF ACUTE UNILATERAL RENAL DENERVATION IN RAT [J].

BELLOREUSS, E ;

COLINDRES, RE ;

PASTORIZAMUNOZ, E ;

MUELLER, RA ;

GOTTSCHALK, CW .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (01) :208-217

[3]

CERUTTI C, 1985, J PHARMACOL METHOD, V13, P249, DOI 10.1016/0160-5402(85)90025-7

[4] BRAIN, SPINAL-CORD AND ADRENAL CATECHOLAMINE CONCENTRATIONS IN NEONATE RATS OF THE LYON HYPERTENSIVE STRAIN [J].

DENOROY, L ;

SAUTEL, M ;

SACQUET, J ;

VINCENT, M ;

SASSARD, J .

NEUROSCIENCE LETTERS, 1985, 58 (02) :165-170

[5] RENAL MANIFESTATIONS OF NACL SENSITIVITY IN BORDERLINE HYPERTENSIVE RATS [J].

DIBONA, GF ;

JONES, SY .

HYPERTENSION, 1991, 17 (01) :44-53

[6] RENAL DENERVATION AT WEANING RETARDS DEVELOPMENT OF HYPERTENSION IN NEW-ZEALAND GENETICALLY HYPERTENSIVE RATS [J].

DIZ, DI ;

NASJLETTI, A ;

BAER, PG .

HYPERTENSION, 1982, 4 (03) :361-368

[7] RENAL PRESSOR REFLEX - INVOLVEMENT OF SYMPATHETIC VASOCONSTRICTOR MECHANISMS [J].

FABER, JE ;

GETTES, DR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 252 (06) :H1147-H1158

[8] INTRAARTERIAL PRESSURE ALTERATIONS DURING TAIL-CUFF BLOOD-PRESSURE MEASUREMENTS IN NORMOTENSIVE AND HYPERTENSIVE RATS [J].

FERRARI, AU ;

DAFFONCHIO, A ;

ALBERGATI, F ;

BERTOLI, P ;

MANCIA, G .

JOURNAL OF HYPERTENSION, 1990, 8 (10) :909-911

[9] HETEROGENEOUS COMPUTER NETWORK FOR REAL-TIME HEMODYNAMIC SIGNAL-PROCESSING [J].

GUSTIN, MP ;

CERUTTI, C ;

PAULTRE, CZ .

COMPUTERS IN BIOLOGY AND MEDICINE, 1990, 20 (03) :205-215

[10] ROLE OF SENSORY RENAL NERVES IN THE DEVELOPMENT OF SPONTANEOUS HYPERTENSION IN RATS [J].

JANSSEN, BJA ;

DEBETS, JJM ;

STRUYKERBOUDIER, HAJ ;

SMITS, JFM .

CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1987, 9 :227-239

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