THE CARCINOGENICITY OF SOME ANTIMALARIAL-DRUGS USING THE EGYPTIAN TOAD BUFO-REGULARIS AS A BIOLOGICAL TEST ANIMAL

被引：9

作者：

ELMOFTY, MM

KHUDOLEY, VV

SAKR, SA

ABDELGAWAD, HS

机构：

[1] Department of Zoology, Faculty of Science, Alexandria University, Alexandria

[2] Petrov Institute for Clinical Oncology, Saint Petersburg

[3] Department of Zoology, Faculty of Science, Menoufia University, Shebin El-kom

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1992年 / 18卷 / 02期

关键词：

D O I：

10.1080/01635589209514219

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Feeding EgyPtian toads (Bufo regularis) with chloroquine and primaquine separately induced tumor formation in 14% and 19% of the animals, respectively. When chloroquine and Primaquine were given in combination, the tumor incidence increased to 23.5%. Chloroquine feeding resulted in tumors located in the liver (lymphosarcomas) and primaquine in tumors in the kidney (histiocytic sarcomas). Toads fed chloroquine plus primaquine developed tumors in the liver, kidney, lung, and urinary bladder, and all the tumors were diagnosed as histiocytic sarcomas. It is speculated that one or more metabolites of chloroquine and primaquine (e. g., quinone) may be responsible for tumor induction in the toads.

引用

页码：191 / 198

页数：8

共 26 条

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