MONOKINES INHIBITING ERYTHROPOIETIN PRODUCTION IN HUMAN HEPATOMA CULTURES AND IN ISOLATED PERFUSED RAT KIDNEYS

被引：185

作者：

JELKMANN, W ^{[1
]}

PAGEL, H ^{[1
]}

WOLFF, M ^{[1
]}

FANDREY, J ^{[1
]}

机构：

[1] MED UNIV LUBECK,W-2400 LUBECK,GERMANY

来源：

LIFE SCIENCES | 1992年 / 50卷 / 04期

关键词：

D O I：

10.1016/0024-3205(92)90338-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The blood level of erythropoietin (Epo) is often anomalously low in anemic patients with inflammatory or malignant diseases. Therefore, we studied effects of pure recombinant immunomodulatory peptides on Epo formation in cultures of the human hepatoma cell line, HepG2. Interleukin (IL)-1-beta, IL-1-alpha, and tumor necrosis factor alpha lowered Epo production with half-maximal inhibition at 2, 5, and 20 U/ml, respectively. IL-6, transforming growth factor beta-2 and interferon gamma did not inhibit. Furthermore, IL-1-beta (10 U/ml) proved to block Epo formation in isolated serum-free perfused rat kidneys. Proposedly, monokines play a role in the pathogenesis of Epo deficiency in various diseases.

引用

页码：301 / 308

页数：8

共 36 条

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