SYNTHESIS OF CONFORMATIONALLY CONSTRAINED MACROCYCLIC ANALOGS OF THE POTENT AND SELECTIVE CCK-B ANTAGONIST CI-988

被引：14

作者：

BOLTON, GL

ROTH, BD

TRIVEDI, BK

机构：

[1] Department of Medicinal Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, MI 48105

来源：

TETRAHEDRON | 1993年 / 49卷 / 03期

关键词：

D O I：

10.1016/S0040-4020(01)86257-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of conformationally constrained analogs of the potent CCK-B antagonist CI-988 were prepared and evaluated for their CCK-B binding affinity. A macrolactamization reaction leading to the formation of 11 to 14-membered rings was also investigated.

引用

页码：525 / 536

页数：12

共 13 条

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