THE VERSATILE STEROID NUCLEUS - DESIGN AND SYNTHESIS OF A PEPTIDOMIMETIC EMPLOYING THIS NOVEL SCAFFOLD

被引：46

作者：

HIRSCHMANN, R

SPRENGELER, PA

KAWASAKI, T

LEAHY, JW

SHAKESPEARE, WC

SMITH, AB

机构：

[1] Department of Chemistry, University of Pennsylvania, Philadelphia

来源：

TETRAHEDRON | 1993年 / 49卷 / 17期

关键词：

D O I：

10.1016/S0040-4020(01)90222-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The design and synthesis of peptidomimetic 1 employing the novel cyclopentanoperhydrophenanthrene skeleton is described. The large body of steroid literature allows for the introduction of diverse peptidal side chains with precise regio- and stereoselective control. Compound 1 binds to the fibrinogen receptor on blood platelets (GP IIb/IIIa), for which it was designed, with an IC50 of ca. 100 muM.

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页码：3665 / 3676

页数：12

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