INCREASE IN SERUM N-G-HYDROXY-L-ARGININE IN RATS TREATED WITH BACTERIAL LIPOPOLYSACCHARIDE

被引：46

作者：

HECKER, M ^{[1
]}

SCHOTT, C ^{[1
]}

BUCHER, B ^{[1
]}

BUSSE, R ^{[1
]}

STOCLET, JC ^{[1
]}

机构：

[1] UNIV LOUIS PASTEUR STRASBOURG 1, PHARMACOL CELLULAIRE & MOLEC LAB, CNRS, URA 600, F-67401 ILLKIRCH GRAFFENSTADEN, FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 275卷 / 01期

关键词：

BACTERIAL LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; INDUCIBLE; N-G-HYDROXY-L-ARGININE;

D O I：

10.1016/0014-2999(95)00046-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aortic rings isolated from rats 4 h after an injection i.p. of 30 mg/kg Escherichia coli lipopolysaccharide showed a marked hyporeactivity to noradrenaline. This effect was paralleled by an increase in the level of nitrite/nitrate in the serum of lipopolysaccharide-treated rats, indicative of an enhanced nitric oxide (NO) synthase activity. Most important, however, the serum concentration of the NO synthase intermediate, N-G-hydroxy-L-arginine, was also markedly elevated from 3.7 to 15.8 mu M. Circulating N-G-hydroxy-L-arginine may thus represent a sensitive and specific marker of NO synthase activity in vivo.

引用

页码：R1 / R3

页数：3

共 8 条

[1] N-OMEGA-HYDROXY-L-ARGININE, AN INTERMEDIATE IN THE L-ARGININE TO NITRIC-OXIDE PATHWAY, IS A STRONG INHIBITOR OF LIVER AND MACROPHAGE ARGINASE [J].