EXPERIMENTALLY INDUCED PHENYLKETONURIA .2. POTENTIAL INHIBITORS OF PHENYLALANINE HYDROXYLASE

被引：8

作者：

DEGRAW, JI

CORY, M

SKINNER, WA

THEISEN, MC

MITOMA, C

机构：

[1] Departments of Pharmaceutical Chemistry and Biochemistry, Stanford Research Institute, Menlo Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 02期

关键词：

D O I：

10.1021/jm00308a007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of a series of alkylating agents derived from phenylalanine is reported. The compounds were found to be ineffective as inhibitors of phenylalanine hydroxylase. Syntheses are described for 4-bromoacetyl-, 4-bromoacetamido-, 3-chloroacetamido-, and 4-fluoro-3-chloroacetamidophenylalanine. © 1968, American Chemical Society. All rights reserved.

引用

页码：225 / &

共 9 条

[1] EXPERIMENTALLY INDUCED PHENYLKETONURIA .I. INHIBITORS OF PHENYLALANINE HYDROXYLASE
DEGRAW, JI
CORY, M
SKINNER, WA
THEISEN, MC
MITOMA, C
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (01) : 64 - &
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[4] PHENYLALANINE HYDROXYLASE
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[5] MARQUET A, 1962, B SOC CHIM FR, P90
[6] INHIBITORS OF THE ENZYMATIC HYDROXYLATION OF PHENYLALANINE AND TRYPTOPHAN BY RAT LIVER EXTRACT INVITRO
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[J]. LIFE SCIENCES, 1964, 3 (06) : 579 - 587
[7] *DIE SYNTHESE DES PARA-CHLORMETHYL-ACETOPHENONS
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[8] UDENFRIEND S, 1952, J BIOL CHEM, V196, P227
[9] WATT DD, 1964, FED PROC, V23, P146

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