COGNITIVE FUNCTION IN HYPERTENSIVES TREATED WITH ATENOLOL OR PROPRANOLOL

被引：18

作者：

PALAC, DM ^{[1
]}

CORNISH, RD ^{[1
]}

MCDONALD, WJ ^{[1
]}

MIDDAUGH, DA ^{[1
]}

HOWIESON, D ^{[1
]}

BAGBY, SP ^{[1
]}

机构：

[1] VET ADM MED CTR,PORTLAND,OR 97207

来源：

JOURNAL OF GENERAL INTERNAL MEDICINE | 1990年 / 5卷 / 04期

关键词：

beta blockers; cognitive function; hypertension;

D O I：

10.1007/BF02600398

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Study objective:To test reports that beta blockers, particularly lipopbilic forms, impair cognitive function and cause psychiatric disturbances. Design:Randomized, double-blind, controlled crossover trial with eight-week treatment periods. Patients:Sequential sample of 43 male veterans, with untreated diastolic blood pressures (DBP) between 90 and 110 mmHg, aged 35-64 years. Interventions:Propranolol-LA, 80-mg tablets, or atenolol, 50-mg tablets, were given daily, incremented by one tablet at weekly intervals until DBP ≤90 mmHg. Hydrochlorothiazide was added, if necessary. Main results:Repeated-measures ANOVA was performed on all cognitive tests. Cognitive test performance was not affected by beta blocker therapy in seven of nine tests and was enhanced on Trail Making Test. Performance was impaired only on Digit Cancellation. Neither Speilberger's State Trait Anxiety Inventory nor the Beck Depression Inventory was affected by either beta blocker. Conclusions:Atenolol or propranolol therapy does not impair cognitive function or contribute significantly to psychiatric side effects. © 1990 Society of General Internal Medicine.

引用

页码：310 / 318

页数：9

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