FIBROBLAST GROWTH-FACTOR INDUCES BETA-AMYLOID PRECURSOR MESSENGER-RNA IN GLIAL BUT NOT NEURONAL CULTURED-CELLS

被引：57

作者：

QUON, D ^{[1
]}

CATALANO, R ^{[1
]}

CORDELL, B ^{[1
]}

机构：

[1] CALIF BIOTECHNOL INC,2450 BAYSHORE PKWY,MT VIEW,CA 94043

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91735-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of PC12 and C6 cell cultures with recombinant basic fibroblast growth factor results in approximately a five to ten-fold stimulation of β-amyloid precursor mRNA in the C6 astrocytoma cell line but only a slight induction of precursor mRNA in the PC-12 neuronal cell line. Stimulation of expression occurred at a hormone concentration of ∼0.5 to 1 nM and was seen after 2 days. These results suggest that basic fibroblast growth factor may contribute to amyloidosis of Alzheimer's disease. © 1990.

引用

页码：96 / 102

页数：7

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