GENOMIC STRUCTURE AND EXPRESSION OF THE HUMAN FAU GENE - ENCODING THE RIBOSOMAL-PROTEIN S30 FUSED TO A UBIQUITIN-LIKE PROTEIN

被引：59

作者：

KAS, K ^{[1
]}

MICHIELS, L ^{[1
]}

MERREGAERT, J ^{[1
]}

机构：

[1] UNIV INSTELLING ANTWERP,DEPT BIOCHEM,MOL BIOTECHNOL LAB,UNIVERSITEITSPLEIN 1,B-2610 WILRIJK,BELGIUM

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91286-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fau gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly Murine Sarcoma Virus (FBR-MuSV). This virus acquired the fau sequence in its reversed transcriptional orientation. Human and mouse fau cDNA's were identified and both encode a new protein of 133 AA. We show that fau (for FBR-MuSV associated ubiquitiously expressed gene) becomes expressed in all different tissues tested as a 600 bp messenger and we report the genomic structure of the human fau gene. The gene consists of five exons and four introns and the 5′ untranslated region displays characteristic features for a housekeeping gene. Fau encodes the ribosomal protein S30 fused to a Ubiquitin-like protein. © 1992.

引用

页码：927 / 933

页数：7

共 19 条

[1] THE HUMAN UBIQUITIN-52 AMINO-ACID FUSION PROTEIN GENE SHARES SEVERAL STRUCTURAL FEATURES WITH MAMMALIAN RIBOSOMAL-PROTEIN GENES [J].