IMPROVEMENT OF METABOLIC CONTROL DOES NOT NORMALIZE AUDITORY BRAIN-STEM LATENCIES IN SUBJECTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS

被引：13

作者：

VIRTANIEMI, J

KUUSISTO, J

KARJALAINEN, L

KARJALAINEN, S

LAAKSO, M

机构：

[1] Departments of Otolaryngology and Medicine, University of Kuopio, Kuopio

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1995年 / 16卷 / 03期

关键词：

D O I：

10.1016/0196-0709(95)90097-7

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Introduction: In our previous study (Am J Otolaryngol 14:413-418, 1993), we reported that prolonged auditory brainstem response latencies are associated with microvascular complications and the duration of diabetes in patients with insulin-dependent diabetes mellitus (IDDM), To investigate whether short-term improvement in metabolic control also affects ABR-responses, we compared ABR-latencies in subjects with IDDM before and after intensified insulin and diet therapy. Materials and Methods: Auditory brainstem latencies were measured in 13 subjects with IDDM (mean age: 25 years) before and after intensified insulin and diet therapy, The acoustic stimulus was a half sine wave with a duration of 0.250 millisecond and a frequency of 2,000 Hz. The stimulus was presented monaurally with fixed polarity through shielded headphones TDH-39 at repetition rate of 10 Hz and at 90 dB hearing level. All subjects had normal hearing ability. Glycated hemoglobin A(1C) (GHbA(1C)), blood glucose immediately before ABR-measurements, and mean blood glucose during 24 hours before auditory studies were measured before and after intensified therapy. Results: During intensified insulin therapy, GHbA(1C) improved significantly (P < .05) in study subjects. However, no changes were observed in ABR-latencies. We also studied those 10 patients whose blood glucose improved during intensified insulin therapy, Although blood glucose was significantly lower (P < .01) after intensified insulin therapy compared with that at baseline, no changes were observed between ABR-latencies at baseline and follow-up. Conclusion: ABR-latencies were not affected by improvement in metabolic control in patients with IDDM. Our finding suggests that delayed ABR-latencies found in patients with IDDM are not caused by poor metabolic control of diabetes but rather by other mechanisms, for example, microvascular complications. Copyright (C) 1995 by W.B. Saunders Company

引用

页码：172 / 176

页数：5

共 14 条

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