ASSESSMENT OF THE HUMORAL AND CELL-MEDIATED-IMMUNITY AGAINST THE PLASMODIUM-FALCIPARUM VACCINE CANDIDATES CIRCUMSPOROZOITE PROTEIN AND SPF66 IN ADULTS LIVING IN HIGHLY ENDEMIC MALARIOUS AREAS OF PAPUA-NEW-GUINEA

被引：18

作者：

BECK, HP ^{[1
]}

FELGER, I ^{[1
]}

KABINTIK, S ^{[1
]}

TAVUL, L ^{[1
]}

GENTON, B ^{[1
]}

ALEXANDER, N ^{[1
]}

BHATIA, KK ^{[1
]}

ALYAMAN, F ^{[1
]}

HII, J ^{[1
]}

ALPERS, M ^{[1
]}

机构：

[1] PAPUA NEW GUINEA INST MED RES,GOROKA,PAPUA N GUINEA

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 51卷 / 03期

关键词：

D O I：

10.4269/ajtmh.1994.51.356

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To assess natural immunity against the circumsporozoite (CS) protein and the synthetic vaccine SPf66, immunologic studies were carried out in a highly endemic malarious area of Papua New Guinea. Antibody prevalence, antibody titers, and T cell proliferation against both antigens were measured in 214 adults. Immunologic data were analyzed with respect to longitudinal malariologic and morbidity data. Evidence of genetic traits such as glucose-6-phosphate dehydrogenase deficiency and ovalocytosis was analyzed. Antibody prevalence was high, with 79% and 84% for CS protein and SPf66, respectively, while T cell proliferation was infrequent and low, with 14% and 12% responders, respectively. Anti-CS protein antibodies increased with age but showed no association to malaria indices or morbidity. No protective value was observed with T cell responses or with humoral response to SPf66. These results provide a first description of naturally developed immunity against SPf66 and suggest further studies in to fully understand the mechanism of immunity against this antigen.

引用

页码：356 / 364

页数：9

共 34 条

[1]

ALPERS MP, 1992, PAPUA NEW GUINEA MED, V35, P285

[2] IMMUNOGENICITY OF SYNTHETIC PEPTIDES FROM CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM [J].