ALDOL CONDENSATION OF 6-ALKOXY-2,2-DIMETHYLCHROMAN-4-ONES WITH SUBSTITUTED BENZALDEHYDES USING TETRAMETHYLORTHOSILICATE AND POTASSIUM FLUORIDE

被引：2

作者：

CHAMBERS, RJ

MARFAT, A

机构：

[1] Department of Medicinal Chemistry, Pfizer Central Research, Groton, Connecticut

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 04期

关键词：

D O I：

10.1002/jhet.5570320451

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aldol condensation of 6-alkoxy-2,2-dimethylchromanones 1 or 2 with substituted benzaldehydes in the presence of tetramethylorthosilicate and potassium fluoride affords 6-alkoxy-3 -benzylidene-2,2-dimethylchromanones 5-10 while other conventional methods were unsuccessful.

引用

收藏

页码：1401 / 1403

页数：3

相关论文

共 18 条

[1] A SIMPLE ROUTE FOR THE SYNTHESIS OF 4-CHLOROCHROMENES AND CHROMAN-4-ONES [J].

ARIAMALA, G ;

BALASUBRAMANIAN, KK .

TETRAHEDRON LETTERS, 1988, 29 (28) :3487-3488

[2]

BANERJI A, 1984, INDIAN J CHEM B, V23, P885

[3] HETEROGENEOUS CATALYSIS BY SALTS AND SOLVENTS .3. SYNTHESIS OF ALPHA, BETA-UNSATURATED CARBONYL-COMPOUNDS FROM SILYL ENOL ETHERS [J].

BOYER, J ;

CORRIU, RJP ;

PERZ, R ;

REYE, C .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1980, 184 (02) :157-166

[4] CSF-PROMOTED MICHAEL ADDITION IN HETEROGENEOUS CATALYSIS [J].

BOYER, J ;

CORRIU, RJP ;

PERZ, R ;

REYE, C .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (03) :122-123

[5]

BROWNBRIDGE P, 1983, SYNTHESIS-STUTTGART, P1

[6] FRIES REARRANGEMENT OF METHOXYPHENYL 3-METHYLBUT-2-ENOATES [J].

CAMPS, F ;

COLL, J ;

COLOMINA, O ;

MESSEGUER, A .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (02) :363-368

[7]

CHUIT C, 1983, SYNTHESIS-STUTTGART, P294

[8] MICHAEL REACTIONS ON UNSATURATED ALPHA-AMIDES AND BETA-AMIDES ACTIVATED BY THE CSF-SI(OCH3)4 SYSTEM [J].

CHUIT, C ;

CORRIU, RJP ;

PERZ, R ;

REYE, C .

TETRAHEDRON, 1986, 42 (08) :2293-2301

[9] STEREOCHEMICAL PROOF OF EXISTENCE OF NUCLEOPHILIC ACTIVATION AT A SILICON ATOM IN NUCLEOPHILIC-SUBSTITUTION REACTIONS - SUBSTITUTION OF SI-CL-BOND WITH RETENTION OF CONFIGURATION [J].

CORRIU, RJP ;

DABOSI, G ;

MARTINEAU, M .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1978, 154 (01) :33-43

[10] 3-METHYL-2H-1-BENZOPYRAN POTASSIUM CHANNEL ACTIVATORS [J].

GERICKE, R ;

HARTING, J ;

LUES, I ;

SCHITTENHELM, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (10) :3074-3085