ASYMMETRIC PROTONATION OF ENOLATES

被引：50

作者：

POTIN, D

WILLIAMS, K

REBEK, J

机构：

[1] UNIV PITTSBURGH,DEPT CHEM,PITTSBURGH,PA 15260

[2] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 12期

关键词：

D O I：

10.1002/anie.199014201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient chiral proton sources have long been the organic chemist's dream. With the lactam 1 based on Kemp's tricarboxylic acid, cyclic enolates have now been protonated with an enantiomeric excess (ee) of up to 91%. The reason for the high ee values is the asymmetric microenvironment of the acidic NH group.

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页码：1420 / 1422

页数：3

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