SUBSTRATE-SPECIFICITY FOR THE HUMAN ROTAMASE FKBP - A VIEW OF FK506 AND RAPAMYCIN AS LEUCINE (TWISTED AMIDE) PROLINE MIMICS

被引：135

作者：

ALBERS, MW

WALSH, CT

SCHREIBER, SL

机构：

[1] HARVARD UNIV,DEPT CHEM,CAMBRIDGE,MA 02138

[2] HARVARD UNIV,SCH MED,DEPT BIOL CHEM & MOLEC PHARMACOL,BOSTON,MA 02115

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 17期

关键词：

D O I：

10.1021/jo00304a003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The temperature dependence and the substrate specificity at the PI site of the human rotamase enzyme FKBP were examined and support a view of the rotamase inhibitors FK506 and rapamycin as peptidomimetics of a leucine-(twisted amide)-proline dipeptide. © 1990, American Chemical Society. All rights reserved.

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页码：4984 / 4986

页数：3

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