SYNTHESIS OF NOVEL ANGIOTENSIN CONVERTING-ENZYME-INHIBITOR QUINAPRIL AND RELATED-COMPOUNDS - A DIVERGENCE OF STRUCTURE-ACTIVITY-RELATIONSHIPS FOR NON-SULFHYDRYL AND SULFHYDRYL TYPES

被引：76

作者：

KLUTCHKO, S ^{[1
]}

BLANKLEY, CJ ^{[1
]}

FLEMING, RW ^{[1
]}

HINKLEY, JM ^{[1
]}

WERNER, AE ^{[1
]}

NORDIN, I ^{[1
]}

HOLMES, A ^{[1
]}

HOEFLE, ML ^{[1
]}

COHEN, DM ^{[1
]}

ESSENBURG, AD ^{[1
]}

KAPLAN, HR ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PHARMACEUT RES,DEPT PHARMACOL,ANN ARBOR,MI 48106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1986年 / 29卷 / 10期

关键词：

D O I：

10.1021/jm00160a026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1953 / 1961

页数：9

共 37 条

[1]

ANDERSON JA, 1984, FED PROC, V43, P733

[2] CONFORMATIONAL-ANALYSIS AND ACTIVE-SITE MODELING OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS [J].

ANDREWS, PR ;

CARSON, JM ;

CASELLI, A ;

SPARK, MJ ;

WOODS, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (03) :393-399

[3]

BECKER RHA, 1983, NAUNYNSCHMIEDEBERGS, P324

[4]

Blankley C. J., 1985, US Patent, Patent No. [4,503,043, 4503043]

[5]

BLANKLEY CJ, 1983, 185TH ACS NAT M SEAT

[6]

CIGNARELLA G, 1976, GAZZ CHIM ITAL, V106, P65

[7]

COHEN DM, 1985, NEW DRUGS ANN CARDIO, V3, P71

[8]

COHEN DM, 1984, PHARMACOLOGIST, V26, P266

[9] ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - IMPORTANCE OF THE AMIDE CARBONYL OF MERCAPTOACYL AMINO-ACIDS FOR HYDROGEN-BONDING TO THE ENZYME [J].

CONDON, ME ;

PETRILLO, EW ;

RYONO, DE ;

REID, JA ;

NEUBECK, R ;

PUAR, M ;

HEILKES, JE ;

SABO, EF ;

LOSEE, KA ;

CUSHMAN, DW ;

ONDETTI, MA .

JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :250-258

[10] DESIGN OF POTENT COMPETITIVE INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME - CARBOXYALKANOYL AND MERCAPTOALKANOYL AMINO-ACIDS [J].

CUSHMAN, DW ;

CHEUNG, HS ;

SABO, EF ;

ONDETTI, MA .

BIOCHEMISTRY, 1977, 16 (25) :5484-5491

← 1 2 3 4 →