LEUKOTRIENES AS A TARGET IN ASTHMA THERAPY

Asthma is a chronic inflammatory condition characterised by bronchial hyper-responsiveness and reversible airways obstruction. Research has demonstrated that these effects are mediated by a wide range of compounds. In the last decade leukotrienes have been identified as products of arachidonic acid metabolism. Their effects mimic the pathological changes seen in asthma both in vitro and in vivo. Further research has demonstrated increased production of leukotrienes both during episodes of asthma and in patients with stable asthma.