NUCLEOSOME POSITIONING AND GENE-REGULATION

被引：70

作者：

LU, Q ^{[1
]}

WALLRATH, LL ^{[1
]}

ELGIN, SCR ^{[1
]}

机构：

[1] WASHINGTON UNIV, DEPT BIOL, ST LOUIS, MO 63130 USA

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 1994年 / 55卷 / 01期

关键词：

CHROMATIN STRUCTURE; PRESET/REMODELING; GENE REPRESSION/ACTIVATION; NUCLEOSOME POSITIONING; REPRESSORS;

D O I：

10.1002/jcb.240550110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent genetic and biochemical studies have revealed critical information concerning the role of nucleosomes in eukaryotic gene regulation. Nucleosomes package DNA into a dynamic chromatin structure, and by assuming defined positions in chromatin, influence gene regulation. Nucleosomes can serve as repressors, presumably by blocking access to regulatory elements; consequently, the positions of nucleosomes relative to the location of cis-acting elements are critical. Some genes have a chromatin structure that is ''preset,'' ready for activation, while others require ''remodeling'' for activation. Nucleosome positioning may be determined by multiple factors, including histone-DNA interactions, boundaries defined by DNA structure or protein binding, and higher-order chromatin structure. (C) 1994 Wiley-Liss, Inc.

引用

页码：83 / 92

页数：10