DIFFERENTIAL CELLULAR-LOCALIZATION OF ESTROGEN-RECEPTOR IMMUNOREACTIVITY AND OXYTOCIN MESSENGER-RNA AND IMMUNOREACTIVITY IN THE RAT PREOPTIC AREA

被引:4
作者
CRUTTWELL, CJ [1 ]
HERBISON, AE [1 ]
BICKNELL, RJ [1 ]
机构
[1] BABRAHAM INST, NEUROENDOCRINOL LAB, CAMBRIDGE CB2 4AT, ENGLAND
关键词
ESTROGEN RECEPTOR; IMMUNOCYTOCHEMISTRY; MESSENGER RNA; OXYTOCIN; PREOPTIC AREA; RAT;
D O I
10.1016/0304-3940(95)12075-F
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Oestrogen influences both oxytocin mRNA and peptide immunoreactivity in the preoptic area and the rat oxytocin gene contains functional oestrogen response elements. However, using combinations of immunocytochemistry and in situ hybridization for oxytocin and oestrogen receptor, we found that preoptic oxytocin neurones do not possess oestrogen receptors. This finding implies oestrogen actions on oxytocin synthesis in preoptic neurones are unlikely to be mediated directly.
引用
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页码:89 / 92
页数:4
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