MECHANISM OF CYCLOSPORINE-INDUCED HYPERTENSION

被引:87
作者
LUKE, RG
机构
[1] Department of Internal Medicine, Cincinnati, OH
关键词
CYCLOSPORINE; IATROGENIC HYPERTENSION; TRANSPLANTS;
D O I
10.1093/ajh/4.5.468
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Cyclosporine is a common immunosuppressive agent used in solid organ and bone marrow transplants and the treatment of some immunological diseases. It has been established that treatment with cyclosporine can cause a patient to develop hypertension within a few weeks of treatment. This review will examine this effect and effective ways to treat it.
引用
收藏
页码:468 / 471
页数:4
相关论文
共 17 条
[1]  
Cohen D.J., Loertscher R., Rubin M.F., Et al., Cyclosporine: Anew immunosuppressive agent for organ transplantation, Ann Intern Med, 101, pp. 667-682, (1984)
[2]  
Curtis J.J., Luke R.G., Dubovsky E., Et al., Cyclosporine intherapeutic doses increases renal allograft vascular resistance, Lancet, 2, pp. 477-479, (1986)
[3]  
Bellet M., Cabrol C., Sassano P., Et al., Systemic hypertension after cardiac transplantation: Effect of cyclosporineon the renin-angiotensin system, Am J Cardiol, 56, pp. 927-931, (1985)
[4]  
Luke R.G., Hypertension in renal transplant recipients, Kidney Int, 31, pp. 1024-1037, (1986)
[5]  
Conte G., Canton A.D., Sabbatini M., Et al., Acute cyclosporine renal dysfunction reversed by dopamine infusion in health subjects, Kidney Int, 36, pp. 1086-1092, (1989)
[6]  
Badr K.F., Ichikawa I., Prerenal failure: A deleterious shiftfrom renal compensation to decompensation, N Eng JMed, 319, pp. 623-629, (1988)
[7]  
Moss N.G., Powell S.L., Falk R.J., Intravenous cyclosporineactivates afferent and efferent renal nerves and causessodium retention in enervated kidneys in rats, Proc NatlAcad Sci, 82, pp. 8222-8226, (1985)
[8]  
Perico N.A., Benigni C., Zoja F., Et al., Functional significance of exaggerated renal thromboxane A2synthete Physiol, 20, pp. F581-F587
[9]  
Pfeilschifter J., Ruegg U.T., Cyclosporin A augments angiotensin II-stimulated rise in intracellular free calciumin vascular smooth muscle cells, Biochem J, 248, pp. 883-887, (1987)
[10]  
Garr M.D., Palier M.S., Cyclosporine augments renal butnot systemic vascular reactivity, Am J Physiol, pp. F211-F217, (1990)