未找到相关数据
THE FREQUENCY OF THE DELTA-F508 MUTATION ON CYSTIC-FIBROSIS CHROMOSOMES IN ISRAELI FAMILIES - CORRELATION TO CF HAPLOTYPES IN JEWISH COMMUNITIES AND ARABS
被引：16
作者：
LERER, I
COHEN, S
CHEMKE, M
SANILEVICH, A
RIVLIN, J
GOLAN, A
YAHAV, J
FRIEDMAN, A
ABELIOVICH, D
机构：
[1] HADASSAH UNIV HOSP,MOLEC BIOL UNIT,JERUSALEM,ISRAEL
[2] KAPLAN HOSP,CLIN GENET UNIT,IL-76100 REHOVOT,ISRAEL
[3] SOROKA UNIV HOSP,BEER SHEVA,ISRAEL
[4] CHAIM SHEBA MED CTR,IL-52621 TEL HASHOMER,ISRAEL
关键词：
D O I：
10.1007/BF02428288
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ;
090102 ;
摘要：
We have analysed the distribution of the ΔF508 mutation and the haplotypes of cystic fibrosis (CF) bearing chromosomes among the Israeli CF population. The population was classified according to its ethnic origin and included 3 groups, Ashkenazi Jews, Sephardic/Oriental Jews and Arabs. Haplotype B (KM19 allele 2, XV2c allele 1) was found to be the predominant haplotype in all groups but in each of them the haplotype distribution was different. The ΔF508 mutation was present in all groups and accounts for 32% of the CF mutations. It was mainly associated with the B haplotype but only one third of the CF chromosomes with this haplotype carry the ΔF508 mutation. © 1990 Springer-Verlag.
引用
收藏
页码：416 / 417
页数：2
相关论文