A LIPOXYGENASE PATHWAY OF ARACHIDONIC-ACID METABOLISM MEDIATES FMRFAMIDE ACTIVATION OF A POTASSIUM CURRENT IN AN IDENTIFIED NEURON OF HELISOMA

被引：19

作者：

BAHLS, FH

RICHMOND, JE

SMITH, WL

HAYDON, PG

机构：

[1] Signal Transduction Training Group, Department of Zoology and Genetics, Science II, Ames

来源：

NEUROSCIENCE LETTERS | 1992年 / 138卷 / 01期

关键词：

POTASSIUM CONDUCTANCE; FMRFAMIDE; ARACHIDONIC ACID; PRESYNAPTIC INHIBITION;

D O I：

10.1016/0304-3940(92)90497-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide FMRFanmide causes a presynaptic inhibition of neurotransmitter release from neuron B5 of Helisoma. In this study we demonstrate that one of FMRFamide's actions is to activate an outwardly rectifying potassium current. Arachidonic acid also activates an outward current in B5. The phospholipase A2 inhibitor, 4-bromoplienacylbromide (BPB), and nordihydroguaiaretic acid (NDGA), an inhibitor of arachidonic acid metabolism, but not indomethacin, block FMRFamide's activation of the potassium current. Taken together these data demonstrate that one of FMRFamide's presynaptic actions is to activate a potassium current through a lipoxygenase pathway of arachidonic acid metabolism.

引用

页码：165 / 168

页数：4

共 16 条

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