A RANDOMIZED CONTROLLED-STUDY OF LOW-DOSE AND HIGH-DOSE TERLIPRESSIN IN THE CONTROL OF ACUTE ESOPHAGEAL VARICEAL HEMORRHAGE

被引:11
作者
CHANG, TT
LEE, FY
TSAI, YT
LAI, KH
CHAO, Y
HSIA, HC
LIN, HC
WANG, SS
LEE, SD
LO, KJ
机构
[1] TAICHUNG VET GEN HOSP, DEPT MED, 160 SEC, 3 CHUNG KANG RD, TAICHUNG 40705, TAIWAN
[2] TAIPEI VET GEN HOSP, DEPT MED, DIV GASTROENTEROL, TAIPEI, TAIWAN
[3] NATL YANG MING MED COLL, TAIPEI, TAIWAN
关键词
1-TRIGLYCYL-8-LYSINE-VASOPRESSIN (TERLIPRESSIN); VARICEAL BLEEDING;
D O I
10.1111/j.1440-1746.1991.tb00892.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A randomized controlled trial was designed to investigate whether a high dose of terlipressin could control acute variceal haemorrhage more effectively than a low dose of terlipressin. Forty cirrhotic patients with bleeding oesophageal varices were included, with low-dose terlipressin in 21 patients and high-dose terlipressin in 19 patients. The two groups of patients were similarly matched for all parameters on admission. High-dose terlipressin (84%) seemed to be more effective in the initial control of bleeding than low-dose terlipressin (67%); however this difference was not significant. Complete control of bleeding during 24 h of drug infusion was achieved in 53% of patients receiving high-dose terlipressin and in 48% of those treated with low-dose terlipressin (P > 0.05). There were no major complications in either group. Mortality in relation to variceal bleeding and transfusion requirements were similar in the two groups. This study shows that high dose terlipressin is not superior to low dose terlipressin in acute variceal bleeding.
引用
收藏
页码:481 / 484
页数:4
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